Stocktwits report covering Puma Biotechnology Inc (PBYI) market action, institutional positioning, and fundamental catalysts.
Why PBYI Stock dropped -2.49% Today — RQD Quant Desk Flash
Puma Biotechnology Inc (PBYI) earns a Roarable Rating of B- (Buy) with 70/100 RQD Confidence. High-quality cash engine (74.5% gross margin, 29% return on capital) with steady institutional support. The company’s underlying cash engine and institutional positioning keep the composite score in the Green Buy zone.
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Is PBYI stock a Buy, Hold, or Sell right now according to Roarable's RQD model?
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As of 2026-11-03, Puma Biotechnology Inc (NASDAQ: PBYI) is rated B- (Buy / BUY) by Roarable's 5-pillar RQD engine with a composite confidence score of 70/100 at a spot price of $10.18 (-2.49% 1D, market cap $538.9M). Pillar breakdown: Fundamental Cash Engine 14/20, Institutional 13F & Options Flow 13/20, SEC Balance-Sheet Forensics 9/20, FRED Macro Regime Fit 17/20, and Executive Insider Alignment 17/20. Across 1015 tracked Health Care issuers, PBYI ranks #78 in composite RQD confidence.
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How does PBYI compare to DRUG and EVO in the Health Care sector?
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Within the Health Care sector (Biotechnology: Pharmaceutical Preparations), PBYI carries a Roarable B- (70/100 RQD), trailing P/E of 17.5x, gross margin of 74.5%, and ROIC of 29.3%. By comparison, DRUG (Bright Minds Biosciences Inc.) holds a D grade (46/100 RQD, P/E N/A, ROIC —, cap $539.9M) and EVO (Evotec SE) posts a D grade (47/100 RQD, P/E N/A, ROIC —, cap $544.3M). Among the 5-stock peer group, PBYI leads on earnings multiple (17.5x) while PBYI leads on capital efficiency (29.3% ROIC).
🤖 Gideon Ashmere • AI SEC 10-K Forensics (Click for Instant Brief)
What are the biggest fundamental strengths and SEC risk factors for PBYI?
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Per PBYI's SEC EDGAR XBRL 10-K filing (FY2025, filed 2025-12-31, CIK 0001401667), Puma Biotechnology Inc generated $228.4M in revenue (-0.9% YoY), $31.1M in net income, and $41.7M in free cash flow against $216.3M in total assets and $0 in total debt. Key quantitative strengths: Company leadership has skin in the game with net positive insider conviction. Primary risk factors monitored: Recent SEC filings added new risk-factor disclosures that warrant keeping an eye on margins. Institutional options positioning shows a 50% call / 50% put premium split.
Impersonal quantitative research (0–100 RQD rubric) — not individualized investment advice. Past performance does not guarantee future results. Full Disclaimer
FRED Regime × Technicals: 81% of 52W Range • RSI-14 at 52.6 (NEUTRAL RANGE)
SEC Form 4 / 13F Thermometer: 85% Net Buy • Cannibal Buyback (-2.64% YoY Shares)
Balance-sheet & 10-K footnote risk deducts 11 pts from forensic ceiling
⚔️ Adversarial Opposing Case: Why the PBYI Bull Thesis Could Fail
Even with a 70/100 (B-) score, PBYI faces multiple-compression risk if 17.5x trailing P/E re-rate toward historical sector medians or if hyperscaler/enterprise customer concentration slows in upcoming 10-Q filings.
Recent SEC filings added new risk-factor disclosures that warrant keeping an eye on margins.
Dilution & Margin Drag: Cannibal Buyback (-2.64% YoY Shares) — any gross margin slip below 72.0% triggers an automatic RQD downgrade.
Technical & Forensic Kill-Switch: A daily close below the 50D SMA ($9.87) or 200D SMA ($7.95) invalidates the momentum regime and cuts Target Base ($10.73) toward Bear Floor ($8.35).
Why PBYI Stock dropped -2.49% Today — RQD Quant Desk Flash
Puma Biotechnology Inc (PBYI) dropped -2.49% to $10.18, trading at 81% of its 52-week range ($4.58 – $11.5). High-quality cash engine (74.5% gross margin, 29% return on capital) with steady institutional support.
- ▸Technical Tape: Trading at 81% of its 52-week range ($4.58 – $11.5) with RSI-14 at 52.6 (NEUTRAL RANGE).
- ▸Volatility Profile: Historical 20-day realized swing band of ±8.9% around $10.18 (no active unusual options sweep snapshot on file).
- ▸Fundamental Anchor: Roarable B- (Buy) backed by 74.5% gross margin and $41.7M annual free cash flow.
Yahoo Finance report covering Puma Biotechnology Inc (PBYI) market action, institutional positioning, and fundamental catalysts.
Investing.com report covering Puma Biotechnology Inc (PBYI) market action, institutional positioning, and fundamental catalysts.
TradingView report covering Puma Biotechnology Inc (PBYI) market action, institutional positioning, and fundamental catalysts.
Benzinga report covering Puma Biotechnology Inc (PBYI) market action, institutional positioning, and fundamental catalysts.
Yahoo Finance report covering Puma Biotechnology Inc (PBYI) market action, institutional positioning, and fundamental catalysts.
ad-hoc-news.de report covering Puma Biotechnology Inc (PBYI) market action, institutional positioning, and fundamental catalysts.
Yahoo Finance report covering Puma Biotechnology Inc (PBYI) market action, institutional positioning, and fundamental catalysts.
AZN, RHHBY, PBYI and OLMA offer exposure to breast cancer drug sales growth, expanded treatment approvals and clinical milestones that could shape prospects.
Scheduled RQD Strong Buys & Whale Accumulation Briefing (PBYI Tape Review)
- ✓Breakdown of the highest-scoring RQD Green-Light breakouts across our 5,200+ rated universe
- ✓Forensic Red-Light accounting & dilution traps to review on your watchlist
- ✓Includes downloadable .ics calendar invite & nightly RQD rating-change email alerts
PBYI Dilution Monitor, Expectations Hurdle, Butterfly Connections & Policy Exposure
Multi-year comparable XBRL diluted share count not disclosed (ETF or recent listing).
vs. -0.9% actual YoY revenue growth (assuming 9.25% cost of equity & 16.5x terminal multiple).
No active Ellis Vennor swing setup published on PBYI today. View full Setup Ledger →
No direct multi-tier Butterfly edges indexed yet for PBYI. Explore sector supply chains on /butterfly.
📊 Quantitative Sector Peer Comparison, SEC Filing Delta & Investment FAQ (PBYI)
1. Head-to-Head Health Care Peer Comparison (PBYI vs. DRUG, EVO, NGNE, STTK)
Industry: Biotechnology: Pharmaceutical Preparations (489 Tracked Issuers)Across 1015 tracked Health Care securities in the Roarable RQD universe, Puma Biotechnology Inc (PBYI) ranks #78 by composite RQD confidence (70/100, grade B-) and #429 by equity capitalization ($538.9M). Within this direct 5-issuer industry benchmark cohort, PBYI leads on earnings valuation at 17.5x trailing P/E, while PBYI leads on capital efficiency and profitability with 29.3% ROIC and 74.5% gross margin. PBYI currently leads its immediate peer cohort in composite quantitative strength at 70/100 (B-).
| Ticker / Company | Roarable Grade | RQD Score | Trailing P/E | Gross Margin | ROIC | 1D Change | Market Cap | Head-to-Head |
|---|---|---|---|---|---|---|---|---|
| PBYI
ACTIVE
Puma Biotechnology Inc | B- | 70/100 | 17.5x | 74.5% | 29.3% | -2.49% | $538.9M | Benchmark Subject |
| DRUG Bright Minds Biosciences Inc. | D | 46/100 | — | — | — | -52.35% | $539.9M | /drug-vs-pbyi → |
| EVO Evotec SE | D | 47/100 | — | — | — | -0.65% | $544.3M | /evo-vs-pbyi → |
| NGNE Neurogene Inc. | D- | 36/100 | — | — | -35.0% | -3.41% | $551.3M | /ngne-vs-pbyi → |
| STTK Shattuck Labs Inc. | E | 29/100 | — | — | -35.0% | -4.32% | $558.0M | /sttk-vs-pbyi → |
2. Multi-Year SEC XBRL Revenue, Cash Flow & Balance-Sheet Trajectory (FY2023–FY2025)
SEC EDGAR 10-K • FILED 2025-12-31 • CIK 0001401667 ↗In its most recent audited fiscal period (FY2025, filed 2025-12-31), Puma Biotechnology Inc (PBYI) reported GAAP revenue of $228.4M (-0.9% vs. FY2024 revenue of $230.5M , and -3.1% cumulative change since FY2023) , GAAP net income of $31.1M, operating cash flow of $41.8M, and free cash flow of $41.7M (+7.4% YoY). On the balance sheet, PBYI closed FY2025 with $216.3M in total assets against $0 in total debt (Altman Z-Score: 0.20, Piotroski F-Score: 8/9).
| Fiscal Period | Filing Date | Revenue | Net Income | Operating Cash Flow | Free Cash Flow | Total Assets | Total Debt |
|---|---|---|---|---|---|---|---|
| FY2025 (FY) | 2025-12-31 | $228.4M | $31.1M | $41.8M | $41.7M | $216.3M | $0 |
| FY2024 (FY) | 2024-12-31 | $230.5M | $30.3M | $38.9M | $38.9M | $213.3M | $21.7M |
| FY2023 (FY) | 2023-12-31 | $235.6M | $21.6M | $27.0M | $27.0M | — | — |
3. PBYI Data-Verified Investor FAQ (RQD Rating, Sector Peers, SEC Forensics & Technicals)
✓ SCHEMA.ORG FAQPAGE JSON-LD ENABLEDIs PBYI stock a Buy, Hold, or Sell right now according to Roarable's RQD model?
As of 2026-11-03, Puma Biotechnology Inc (NASDAQ: PBYI) is rated B- (Buy / BUY) by Roarable's 5-pillar RQD engine with a composite confidence score of 70/100 at a spot price of $10.18 (-2.49% 1D, market cap $538.9M). Pillar breakdown: Fundamental Cash Engine 14/20, Institutional 13F & Options Flow 13/20, SEC Balance-Sheet Forensics 9/20, FRED Macro Regime Fit 17/20, and Executive Insider Alignment 17/20. Across 1015 tracked Health Care issuers, PBYI ranks #78 in composite RQD confidence.
How does PBYI compare to DRUG and EVO in the Health Care sector?
Within the Health Care sector (Biotechnology: Pharmaceutical Preparations), PBYI carries a Roarable B- (70/100 RQD), trailing P/E of 17.5x, gross margin of 74.5%, and ROIC of 29.3%. By comparison, DRUG (Bright Minds Biosciences Inc.) holds a D grade (46/100 RQD, P/E N/A, ROIC —, cap $539.9M) and EVO (Evotec SE) posts a D grade (47/100 RQD, P/E N/A, ROIC —, cap $544.3M). Among the 5-stock peer group, PBYI leads on earnings multiple (17.5x) while PBYI leads on capital efficiency (29.3% ROIC).
What are the biggest fundamental strengths and SEC risk factors for PBYI?
Per PBYI's SEC EDGAR XBRL 10-K filing (FY2025, filed 2025-12-31, CIK 0001401667), Puma Biotechnology Inc generated $228.4M in revenue (-0.9% YoY), $31.1M in net income, and $41.7M in free cash flow against $216.3M in total assets and $0 in total debt. Key quantitative strengths: Company leadership has skin in the game with net positive insider conviction. Primary risk factors monitored: Recent SEC filings added new risk-factor disclosures that warrant keeping an eye on margins. Institutional options positioning shows a 50% call / 50% put premium split.
Where is PBYI trading relative to its 50-day, 200-day, and 52-week technical levels?
PBYI last traded at $10.18 (-2.49% on volume of 399,317 shares), positioning the stock +3.14% above its 50-day simple moving average ($9.87) and +28.05% above its 200-day simple moving average ($7.95). Across its 52-week range of $4.58 to $11.50, PBYI sits at the 80.9% percentile with a 14-day RSI of 52.6 (NEUTRAL RANGE) and an implied next-earnings move of ±8.9% ($9.27 to $11.09).
PBYI — Puma Biotechnology Inc: What the Facts Mean to a Prospective Investor
1. Roarable Rating Brief: What This Means to a Prospective Investor
Puma Biotechnology Inc (PBYI) earns a live Roarable RQD composite score of 70/100, corresponding to a B- letter grade (Roarable Buy) at a spot price of $10.18 (-2.49% 1D, market capitalization $538.9M).
- Fundamental Cash Engine (14/20): Anchored by return on invested capital (ROIC) of 29.3%, gross margin of 74.5%, operating margin of 16.3%, and free cash flow yield of 7.67%.
- Whale 13F & Options Flow (13/20) + Insider Conviction (17/20): Tracks institutional 13F accumulation, CBOE options call/put positioning, and SEC Form 4 / Congressional PTR filings.
- Macro Regime Fit (17/20) + Forensic Balance Sheet (9/20): Incorporates a 1.00x equity beta, Altman Z-Score of 0.20, Piotroski F-Score of 8/9, and Debt/Equity of 0.00x.
2. Business Model, Unit Margins & SEC Financial Trajectory
Puma Biotechnology Inc is a NASDAQ-listed issuer in the Health Care sector, operating within the Biotechnology: Pharmaceutical Preparations industry. The market capitalization is $0.5B. — for further detail on what the company sells or to whom.
In its latest audited SEC EDGAR 10-K filing for FY2025 (filed 2025-12-31), Puma Biotechnology Inc (PBYI) reported $228.4M in annual revenue (up from $230.5M in FY2024, -0.9% YoY) and $31.1M in GAAP net income. Over the multi-year SEC filing window from FY2023 ($235.6M revenue, $21.6M net income) through FY2025, PBYI scaled operating cash flow to $41.8M and free cash flow to $41.7M, backed by $216.3M in total assets against $0 in total debt.
3. Institutional Bull vs. Bear Thesis & Valuation Tradeoff
- 🐂 Primary Bull Case (B- • RQD 70/100): Company leadership has skin in the game with net positive insider conviction. Free cash flow yield of 7.67% and institutional whale pillar of 13/20. With Fundamental Cash Engine at 14/20 and Institutional Whale Flow at 13/20, sustained execution supports upside toward the upper end of the $4.58 – $11.50 52-week range.
- 🐻 Primary Bear Case & Valuation Risk: Recent SEC filings added new risk-factor disclosures that warrant keeping an eye on margins. Investors must weigh 17.5x trailing P/E and 13.8x EV/EBITDA against 16.3% operating margins and a 1.00x macro beta.
4. 2nd-Order Butterfly Ripples & Key Questions to Watch
— The Butterfly Supply-Chain Graph records supply_chain as NONE, with empty butterfly_links and proprietary_signals arrays, so upstream and downstream dependencies, sector correlations, and second-order bottlenecks cannot be mapped from the provided sources.
- Key Question #1: Can PBYI sustain or expand its 16.3% operating margin and 29.3% ROIC against Biotechnology: Pharmaceutical Preparations peers over the next 4 quarters?
- Key Question #2: Following FY2025 revenue of $228.4M and free cash flow of $41.7M, how will capital allocation balance growth reinvestment against $0 in total debt?
- Key Question #3: How sensitive is PBYI's 16.3x forward P/E multiple to Health Care capital spending cycles and macro interest-rate shifts (Beta 1.00x)?
PBYI Live News Feed, Press Releases & Catalyst Wire
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Stocktwits report covering Puma Biotechnology Inc (PBYI) market action, institutional positioning, and fundamental catalysts.
Yahoo Finance report covering Puma Biotechnology Inc (PBYI) market action, institutional positioning, and fundamental catalysts.
Investing.com report covering Puma Biotechnology Inc (PBYI) market action, institutional positioning, and fundamental catalysts.
TradingView report covering Puma Biotechnology Inc (PBYI) market action, institutional positioning, and fundamental catalysts.
Benzinga report covering Puma Biotechnology Inc (PBYI) market action, institutional positioning, and fundamental catalysts.
Yahoo Finance report covering Puma Biotechnology Inc (PBYI) market action, institutional positioning, and fundamental catalysts.
ad-hoc-news.de report covering Puma Biotechnology Inc (PBYI) market action, institutional positioning, and fundamental catalysts.
Yahoo Finance report covering Puma Biotechnology Inc (PBYI) market action, institutional positioning, and fundamental catalysts.
PBYI Bull vs. Bear Conversation Board — What's Your Call at $10.18?
The RQD rating's insider-conviction (17/20) and macro-fit (17/20) pillars, combined with a 29.3% ROIC and 7.67% FCF yield, point to a c
The street is overcomplicating Puma Biotechnology Inc (PBYI). The RQD rating's insider-conviction (17/20) and macro-fit (17/20) pillars, combined with a 29.3% ROIC and 7.67% FCF yield, point to a cash-generative business with institutional accumulation behind it.. With an RQD score of 70/100 (B-) and Forensic Balance Sheet at 9/20, any positive earnings surprise or guidance raise forces underweight funds to chase above $11.28.
@CreditSpread_Watch Shorting a 13/20 institutional whale-flow stock at $10.44 is dangerous when funds are rotating into Health Care.
A 0.2 Altman Z-Score and a 9/20 forensic balance-sheet pillar flag financial-distress risk, and the stock trades near the top of its $4
Sitting on the sidelines or leaning short PBYI above $10.44. A 0.2 Altman Z-Score and a 9/20 forensic balance-sheet pillar flag financial-distress risk, and the stock trades near the top of its $4.58–$11.5 52-week range with reported revenue declining since FY 2023.. Until Fundamental Cash Engine (14/20) and FCF yield (7.67%) inflect higher, upside is capped near $11.50.