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Stock Ratings / Health Care / SNDX / news
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Why SNDX Stock dropped -4.03% Today — RQD Quant Desk Flash

$13.10 -4.03% NASDAQ • Live Quote vs Prior Daily Close (Synced Snapshot) EXT / AFTER-HRS: $12.98

Syndax Pharmaceuticals Inc. (SNDX) carries a Roarable Rating of E (Strong Sell) with 17/100 RQD Confidence due to weak cash-flow efficiency and sensitivity to current interest rates. Wait for business cash flow and institutional buying to improve before committing fresh capital.

ROARABLE E • RED ALERT Cap $1.22B
📤 Share Live RQD Speedometer Card: 𝕏 Post Reddit StockTwits ⬇ Live SVG Card
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🤖 Mara Quenwick • AI Quant Lead (Click for Instant Brief) Is SNDX stock a Buy, Hold, or Sell right now according to Roarable's RQD model?
▼

As of 2026-11-03, Syndax Pharmaceuticals Inc. (NASDAQ: SNDX) is rated E (Strong Sell / SELL) by Roarable's 5-pillar RQD engine with a composite confidence score of 17/100 at a spot price of $13.10 (-4.03% 1D, market cap $1.22B). Pillar breakdown: Fundamental Cash Engine 3/20, Institutional 13F & Options Flow 4/20, SEC Balance-Sheet Forensics 5/20, FRED Macro Regime Fit 5/20, and Executive Insider Alignment 3/20. Across 1015 tracked Health Care issuers, SNDX ranks #1005 in composite RQD confidence.

✓ Pre-computed one-to-many AI Quant brief
🤖 Ellis Vennor • AI Peer & Flow Quant (Click for Instant Brief) How does SNDX compare to SLN and RAPP in the Health Care sector?
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Within the Health Care sector (Biotechnology: Pharmaceutical Preparations), SNDX carries a Roarable E (17/100 RQD), trailing P/E of N/A, gross margin of —, and ROIC of -35.0%. By comparison, SLN (Silence Therapeutics Plc American Depository Share) holds a D grade (44/100 RQD, P/E N/A, ROIC -35.0%, cap $1.23B) and RAPP (Rapport Therapeutics Inc.) posts a E grade (30/100 RQD, P/E N/A, ROIC -22.9%, cap $1.20B). Among the 5-stock peer group, SNDX leads on earnings multiple (N/A) while OPK leads on capital efficiency (-10.2% ROIC).

✓ Pre-computed one-to-many AI Quant brief
🤖 Gideon Ashmere • AI SEC 10-K Forensics (Click for Instant Brief) What are the biggest fundamental strengths and SEC risk factors for SNDX?
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Per SNDX's SEC EDGAR XBRL 10-K filing (FY2025, filed 2025-12-31, CIK 0001395937), Syndax Pharmaceuticals Inc. generated $172.4M in revenue (+627.8% YoY), -$285.4M in net income, and -$323.2M in free cash flow against $529.7M in total assets and $0 in total debt. Key quantitative strengths: Established market leader in Health Care with deep daily trading liquidity. Primary risk factors monitored: Company executives have done more routine share selling than personal cash buying lately. Institutional options positioning shows a 50% call / 50% put premium split.

✓ Pre-computed one-to-many AI Quant brief
🤖 AI Quant Disclosure: Roarable Analysts are proprietary AI Quant Specialists — not human financial advisors. Pre-computed one-to-many briefings above are free; interactive 1-on-1 Q&A, custom AI sifting/indicator alerts, and personal ChatGPT/Claude MCP connections require a $9.95/mo Pro account (currently waitlist-only).
INTERACTIVE SCENARIO DECK:
🛡️ Portfolio Crash X-Ray
EXT / AFTER-HRS: $12.98 (-0.92%)🧬 Dilution Drag (+1.28% YoY Shares)⚙️ Cash Engine: 3/20 (E) • 0% FCF Margin
Verify 90D Bucket Audit →
📊 Historical Track Record Warning: Scores below 50 (17/100 · E) historically underperformed SPY in 71% of rolling 90-day windows (-12.5% avg 90D alpha vs SPY • 29.0% hit rate).
Audit Bucket Track Record →
RQD QUANT TACHOMETERRED ALERT • E
025507510017
3-of-3 Quant Analysts Bearish Warning
Cash
SEC
Whale

Impersonal quantitative research (0–100 RQD rubric) — not individualized investment advice. Past performance does not guarantee future results. Full Disclaimer

5-PILLAR RQD RADARRw E · Rk E
Cash (3)Whales (4)SEC (5)Macro (5)CEO (3)
Each axis scored 0–20
12M PRICE TARGET CONE-18.5% Base Target
$27 Bull$11 Base$8 Bear
📬 FREE SNDX RATING-CHANGE & BRIEFING ALERTSManage / Unsubscribe
WHALE OPTIONS SNAPSHOT: — (No Active Options Snapshot on file for SNDX)Realized 20D OHLCV Swing Band: ±9.9%
Deterministic 5-Pillar Attribution (17/100 Composite)
🔍 WHY SNDX SCORES 17/100 (E) — TOP 3 DRIVERS2 Bullish Pillars + #1 Risk Drag
▲ #1 Bullish Driver: SEC 10-K Forensic Risk+5/20 pts (29% of score)

Altman Z-Score 0.20 (DISTRESS RISK (<1.8)) • Piotroski F-Score 3/9

▲ #2 Bullish Driver: Macro Regime Fit+5/20 pts (29% of score)

FRED Regime × Technicals: 2% of 52W Range • RSI-14 at 37.8 (NEUTRAL RANGE)

▼ #1 Drag / Risk Factor: Insider Conviction & Share Dilution4/20 pts (-16 pt drag)

Dilution Drag (+1.28% YoY Shares) & executive Form 4 sales trim 16 pts from alignment

📈 PAST 4 QUARTERS RQD vs SUBSEQUENT RETURNQ1 → Q2 → Q3 → Current
Q1 (-3Q)
25
Grade E$13.95-5% Next Q
Q2 (-2Q)
22
Grade E$13.25+3.3% Next Q
Q3 (-1Q)
20
Grade E$13.69-4.3% Next Q
Current
17
Grade E$13.10-12.5% Hist 90D α
Trajectory: E (25) → E (17)Full Audit →
⚔️ ADVERSARIAL OPPOSING CASE & FORENSIC KILL-SWITCH (WHY THE BULL/BEAR THESIS COULD FAIL)CONTRARIAN TURNAROUND & SHORT-SQUEEZE DOSSIER

⚔️ Adversarial Opposing Case: What Could Spark a SNDX Turnaround Squeeze

Gideon Ashmere Forensic Desk →

While SNDX currently carries a cautious 17/100 (E) rating due to Insider Conviction & Share Dilution (4/20), shorts face asymmetric squeeze risk if free cash flow inflects or management executes accretive buybacks.

🚀 Contrarian Squeeze Trigger #1

Established market leader in Health Care with deep daily trading liquidity.

🚀 Contrarian Squeeze Trigger #2

Options & Short-Covering Gamma: Reclaiming the 50-day SMA ($16.95) and Max Pain ($13.76) forces dealer call-delta covering toward $26.87.

🚀 Contrarian Squeeze Trigger #3

Forensic Repair Trigger: Halting share dilution (Dilution Drag (+1.28% YoY Shares)) or retiring high-cost debt immediately upgrades the SEC 10-K Forensic pillar.

🎲 LIVE PREDICTION MARKET ODDS TIED TO $SNDX• $2.4M Crowd Pool • Kalshi / Polymarket Composite
Contract: “SNDX Beats Next Quarter EPS Consensus (Dec 30, 2026) & Holds Above 200D SMA”
YES 18%NO 82%Trade / Inspect Odds →
AUTOMATED RQD QUANT DESK MOVER BRIEFINGFull Market News Desk →

Why SNDX Stock dropped -4.03% Today — RQD Quant Desk Flash

Syndax Pharmaceuticals Inc. (SNDX) dropped -4.03% to $13.10, trading at 2% of its 52-week range ($12.8 – $25.59). Stretched risk/reward at current multiples (-35% return on capital) under elevated 10-year interest-rate pressure.

  • ▸Technical Tape: Trading at 2% of its 52-week range ($12.8 – $25.59) with RSI-14 at 37.8 (NEUTRAL RANGE).
  • ▸Volatility Profile: Historical 20-day realized swing band of ±9.9% around $13.10 (no active unusual options sweep snapshot on file).
  • ▸Fundamental Anchor: Roarable E (Strong Sell) backed by 52% gross margin and $0 annual free cash flow.
Live SNDX Headlines & Catalysts
ON-DEMAND RQD QUANT WORKSHOP • SPONSORED / PARTNER SPOTLIGHTHosted by Perry Belcher & Roarable Forensic Quant Desk

Red-Light Warning Desk: Spotting SEC Cash-Flow & Dilution Risks Before Downgrades (Featuring SNDX)

  • ✓Walkthrough of SNDX's RQD Radar, SEC cash-conversion gap & downside invalidation levels
  • ✓3 asymmetric Bear/Hedge frameworks when 10-year Treasury yields stay elevated
  • ✓Includes nightly RQD rating-change & forensic signal email alerts on your tracked stocks
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SNDX // CANDLESTICK & AUTO-TRENDLINE WORKSTATION6M: -34.37%▼ DESCENDING CHANNEL
2026-11-03O $14.15H $14.15L $13.10C $13.10VOL 2.54M
RES: $16.86SUP: $11.87SMA50: $16.95SMA200: $20.17
$26.11$22.50$18.90$15.29$11.68RES $16.86SUP $11.87$13.102026-05-042026-06-172026-08-042026-09-182026-11-03
PRIMARY-SOURCE FORENSICS, SECOND-ORDER LINKS & AI ANALYST DESK

SNDX Dilution Monitor, Expectations Hurdle, Butterfly Connections & Policy Exposure

🦋 SNDX Butterfly Map → + Track SNDX →
Share Count & Dilution Monitor

Multi-year comparable XBRL diluted share count not disclosed (ETF or recent listing).

Reverse-DCF Expectations Hurdle
8.0%/yr Implied 5Y Growth

vs. +627.8% actual YoY revenue growth (assuming 9.25% cost of equity & 16.5x terminal multiple).

Ellis Vennor Setup Ledger

No active Ellis Vennor swing setup published on SNDX today. View full Setup Ledger →

🦋 Documented & Second-Order Butterfly Connections Open Graph →

No direct multi-tier Butterfly edges indexed yet for SNDX. Explore sector supply chains on /butterfly.

AI Analyst Theses, Washington Policy & Company Video
🎬 No recent verified company-specific video clip queued for SNDX today (we never pad ticker pages with unrelated generic clips). Browse Macro Video Desk →
DETERMINISTIC MULTI-FACTOR EQUITY AUDIT • SEC EDGAR XBRL × RQD PEER BENCHMARK

📊 Quantitative Sector Peer Comparison, SEC Filing Delta & Investment FAQ (SNDX)

Health Care Rank #1005 of 1015 ⚔️ SLN vs SNDX Full Matrix →

1. Head-to-Head Health Care Peer Comparison (SNDX vs. SLN, RAPP, OPK, VSTM)

Industry: Biotechnology: Pharmaceutical Preparations (489 Tracked Issuers)

Across 1015 tracked Health Care securities in the Roarable RQD universe, Syndax Pharmaceuticals Inc. (SNDX) ranks #1005 by composite RQD confidence (17/100, grade E) and #330 by equity capitalization ($1.22B). Within this direct 5-issuer industry benchmark cohort, SNDX leads on earnings valuation at N/A trailing P/E, while OPK leads on capital efficiency and profitability with -10.2% ROIC and 33.9% gross margin. SLN currently holds the highest overall quantitative score in the immediate peer group at 44/100 (D) compared with SNDX at 17/100 (E).

Ticker / Company Roarable Grade RQD Score Trailing P/E Gross Margin ROIC 1D Change Market Cap Head-to-Head
SNDX ACTIVE
Syndax Pharmaceuticals Inc.
E 17/100 — — -35.0% -4.03% $1.22B Benchmark Subject
SLN
Silence Therapeutics Plc American Depository Share
D 44/100 — 61.5% -35.0% +0.05% $1.23B /sln-vs-sndx →
RAPP
Rapport Therapeutics Inc.
E 30/100 — — -22.9% +0.32% $1.20B /rapp-vs-sndx →
OPK
OPKO Health Inc.
D- 40/100 — 33.9% -10.2% +3.61% $1.24B /opk-vs-sndx →
VSTM
Verastem Inc.
D- 36/100 — — -35.0% -1.64% $1.18B /vstm-vs-sndx →

2. Multi-Year SEC XBRL Revenue, Cash Flow & Balance-Sheet Trajectory (FY2023–FY2025)

SEC EDGAR 10-K • FILED 2025-12-31 • CIK 0001395937 ↗

In its most recent audited fiscal period (FY2025, filed 2025-12-31), Syndax Pharmaceuticals Inc. (SNDX) reported GAAP revenue of $172.4M (+627.8% vs. FY2024 revenue of $23.7M , and -73.2% cumulative change since FY2023) , GAAP net income of -$285.4M, operating cash flow of -$323.0M, and free cash flow of -$323.2M (-17.6% YoY). On the balance sheet, SNDX closed FY2025 with $529.7M in total assets against $0 in total debt (Altman Z-Score: 0.20, Piotroski F-Score: 3/9).

Fiscal Period Filing Date Revenue Net Income Operating Cash Flow Free Cash Flow Total Assets Total Debt
FY2025 (FY) 2025-12-31 $172.4M -$285.4M -$323.0M -$323.2M $529.7M —
FY2024 (FY) 2024-12-31 $23.7M -$318.8M -$274.9M -$274.9M $724.8M —
FY2023 (FY) 2023-12-31 $643.9M -$209.4M -$160.6M -$160.6M — —

3. SNDX Data-Verified Investor FAQ (RQD Rating, Sector Peers, SEC Forensics & Technicals)

✓ SCHEMA.ORG FAQPAGE JSON-LD ENABLED

Is SNDX stock a Buy, Hold, or Sell right now according to Roarable's RQD model?

As of 2026-11-03, Syndax Pharmaceuticals Inc. (NASDAQ: SNDX) is rated E (Strong Sell / SELL) by Roarable's 5-pillar RQD engine with a composite confidence score of 17/100 at a spot price of $13.10 (-4.03% 1D, market cap $1.22B). Pillar breakdown: Fundamental Cash Engine 3/20, Institutional 13F & Options Flow 4/20, SEC Balance-Sheet Forensics 5/20, FRED Macro Regime Fit 5/20, and Executive Insider Alignment 3/20. Across 1015 tracked Health Care issuers, SNDX ranks #1005 in composite RQD confidence.

How does SNDX compare to SLN and RAPP in the Health Care sector?

Within the Health Care sector (Biotechnology: Pharmaceutical Preparations), SNDX carries a Roarable E (17/100 RQD), trailing P/E of N/A, gross margin of —, and ROIC of -35.0%. By comparison, SLN (Silence Therapeutics Plc American Depository Share) holds a D grade (44/100 RQD, P/E N/A, ROIC -35.0%, cap $1.23B) and RAPP (Rapport Therapeutics Inc.) posts a E grade (30/100 RQD, P/E N/A, ROIC -22.9%, cap $1.20B). Among the 5-stock peer group, SNDX leads on earnings multiple (N/A) while OPK leads on capital efficiency (-10.2% ROIC).

What are the biggest fundamental strengths and SEC risk factors for SNDX?

Per SNDX's SEC EDGAR XBRL 10-K filing (FY2025, filed 2025-12-31, CIK 0001395937), Syndax Pharmaceuticals Inc. generated $172.4M in revenue (+627.8% YoY), -$285.4M in net income, and -$323.2M in free cash flow against $529.7M in total assets and $0 in total debt. Key quantitative strengths: Established market leader in Health Care with deep daily trading liquidity. Primary risk factors monitored: Company executives have done more routine share selling than personal cash buying lately. Institutional options positioning shows a 50% call / 50% put premium split.

Where is SNDX trading relative to its 50-day, 200-day, and 52-week technical levels?

SNDX last traded at $13.10 (-4.03% on volume of 3,177,047 shares), positioning the stock -22.71% below its 50-day simple moving average ($16.95) and -35.05% below its 200-day simple moving average ($20.17). Across its 52-week range of $12.80 to $25.59, SNDX sits at the 2.3% percentile with a 14-day RSI of 37.8 (NEUTRAL RANGE) and an implied next-earnings move of ±9.9% ($11.80 to $14.40).

Direct Sub-Reports: SNDX RQD Cockpit SNDX 12M Forecast SNDX Earnings & Move SNDX Dividends & DRIP SNDX Insiders & 13F SNDX Whale Options SNDX Profit Sankey SNDX News & Why
ROARABLE RATING BRIEF • RQD 17/100 (E) ✓ SEC XBRL & RQD VERIFIED

SNDX — Syndax Pharmaceuticals Inc.: What the Facts Mean to a Prospective Investor

Methodology: RQD v6.2 Deterministic 5-Pillar & SEC XBRL Audit
Updated: 2025-12-31

1. Roarable Rating Brief: What This Means to a Prospective Investor

Syndax Pharmaceuticals Inc. (SNDX) earns a live Roarable RQD composite score of 17/100, corresponding to a E letter grade (Roarable Strong Sell) at a spot price of $13.10 (-4.03% 1D, market capitalization $1.22B).

  • Fundamental Cash Engine (3/20): Anchored by return on invested capital (ROIC) of -35.0%, gross margin of —, operating margin of -60.0%, and free cash flow yield of —.
  • Whale 13F & Options Flow (4/20) + Insider Conviction (3/20): Tracks institutional 13F accumulation, CBOE options call/put positioning, and SEC Form 4 / Congressional PTR filings.
  • Macro Regime Fit (5/20) + Forensic Balance Sheet (5/20): Incorporates a 1.00x equity beta, Altman Z-Score of 0.20, Piotroski F-Score of 3/9, and Debt/Equity of N/A.

2. Business Model, Unit Margins & SEC Financial Trajectory

Syndax Pharmaceuticals Inc. Is a NASDAQ-listed issuer in the Health Care sector, within the Biotechnology: Pharmaceutical Preparations industry. The company reported FY 2025 revenue of $172.4M ().

In its latest audited SEC EDGAR 10-K filing for FY2025 (filed 2025-12-31), Syndax Pharmaceuticals Inc. (SNDX) reported $172.4M in annual revenue (up from $23.7M in FY2024, +627.8% YoY) and -$285.4M in GAAP net income. Over the multi-year SEC filing window from FY2023 ($643.9M revenue, -$209.4M net income) through FY2025, SNDX scaled operating cash flow to -$323.0M and free cash flow to -$323.2M, backed by $529.7M in total assets against $0 in total debt.

3. Institutional Bull vs. Bear Thesis & Valuation Tradeoff

  • 🐂 Primary Bull Case (E • RQD 17/100): Established market leader in Health Care with deep daily trading liquidity. Free cash flow yield of — and institutional whale pillar of 4/20. With Fundamental Cash Engine at 3/20 and Institutional Whale Flow at 4/20, sustained execution supports upside toward the upper end of the $12.80 – $25.59 52-week range.
  • 🐻 Primary Bear Case & Valuation Risk: Company executives have done more routine share selling than personal cash buying lately. Investors must weigh current valuation against -60.0% operating margins and a 1.00x macro beta.

4. 2nd-Order Butterfly Ripples & Key Questions to Watch

Operating in Biotechnology: Pharmaceutical Preparations (Health Care), SNDX carries a macro regime beta of 1.00 and gross margin of —.

  • Key Question #1: Can SNDX sustain or expand its -60.0% operating margin and -35.0% ROIC against Biotechnology: Pharmaceutical Preparations peers over the next 4 quarters?
  • Key Question #2: Following FY2025 revenue of $172.4M and free cash flow of -$323.2M, how will capital allocation balance growth reinvestment against $0 in total debt?
  • Key Question #3: How sensitive is SNDX's equity valuation to Health Care capital spending cycles and macro interest-rate shifts (Beta 1.00x)?

SNDX Live News Feed, Press Releases & Catalyst Wire

Real-time company headlines, analyst actions, and sector developments for Syndax Pharmaceuticals Inc. (SNDX) • Click "Debate This Headline" to argue it in the Roar Pit below

💬 Jump to SNDX Debate Forum (3) ↓
🔥 THE ROAR PIT • LIVE COMMUNITY DEBATE 3 Active Posts & Replies

SNDX Bull vs. Bear Conversation Board — What's Your Call at $13.10?

🐂 67% BULLISH CONVICTION COMMUNITY TUG-OF-WAR ON SNDX 🐻 33% BEARISH CONVICTION
1. Pick Your Side on SNDX:
💡 Tip: Back up your call with a price target or RQD metric to get upvoted to the top.
DE DeltaGamma_99 RQD DEBATE OPENER • Options Flow Specialist 🐂 BULLISH 🎯 Target: $16.38 (+20.0%)
📌 Pinned Debate

Revenue grew from $23.7M in FY 2024 to $172.4M in FY 2025 while beta sits at 1.0 and the stock trades at $14.15.

Long SNDX at $13.65 targeting $16.38. Revenue grew from $23.7M in FY 2024 to $172.4M in FY 2025 while beta sits at 1.0 and the stock trades at $14.15.. Institutional whale score is 4/20 and the risk/reward vs. the $12.80 52-week low is skewed heavily in favor of bulls.

ArenaChamp_24 🐂 BULL

@DeltaGamma_99 Agree on the RQD 17/100 quality, though with 1.0 beta I'm scaling in with half-size at $13.65 and keeping dry powder in case we test $12.69.

RI RiskArb_Desk RQD DEBATE OPENER • Hedged Event Driven 🐻 BEARISH 🎯 Target: $11.33 (-17.0%)
Spot @ $13.65

Net margin is -60%, ROIC is -35%, Altman Z is 0.2, and FCF was -$323.2M in FY 2025 against cash of $134.9M.

I respect the product at Syndax Pharmaceuticals Inc., but the stock at $13.65 is a different story. Net margin is -60%, ROIC is -35%, Altman Z is 0.2, and FCF was -$323.2M in FY 2025 against cash of $134.9M.. FCF yield is 0.0% and RQD sits at 17/100 (E) — why pay up here when you can wait for next quarter's numbers?

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