Yahoo Finance report covering Spruce Biosciences Inc. (SPRB) market action, institutional positioning, and fundamental catalysts.
Why SPRB Stock dropped -3.97% Today — RQD Quant Desk Flash
Spruce Biosciences Inc. (SPRB) carries a Roarable Rating of E (Strong Sell) with 34/100 RQD Confidence due to weak cash-flow efficiency and sensitivity to current interest rates. Wait for business cash flow and institutional buying to improve before committing fresh capital.
🤖 Mara Quenwick • AI Quant Lead (Click for Instant Brief)
Is SPRB stock a Buy, Hold, or Sell right now according to Roarable's RQD model?
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As of 2026-11-03, Spruce Biosciences Inc. (NASDAQ: SPRB) is rated E (Strong Sell / SELL) by Roarable's 5-pillar RQD engine with a composite confidence score of 34/100 at a spot price of $44.55 (-3.97% 1D, market cap $133.3M). Pillar breakdown: Fundamental Cash Engine 4/20, Institutional 13F & Options Flow 5/20, SEC Balance-Sheet Forensics 10/20, FRED Macro Regime Fit 10/20, and Executive Insider Alignment 5/20. Across 1015 tracked Health Care issuers, SPRB ranks #633 in composite RQD confidence.
🤖 Ellis Vennor • AI Peer & Flow Quant (Click for Instant Brief)
How does SPRB compare to KZIA and OGI in the Health Care sector?
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Within the Health Care sector (Biotechnology: Pharmaceutical Preparations), SPRB carries a Roarable E (34/100 RQD), trailing P/E of N/A, gross margin of —, and ROIC of -35.0%. By comparison, KZIA (Kazia Therapeutics Limited) holds a D grade (47/100 RQD, P/E N/A, ROIC —, cap $132.2M) and OGI (Organigram Global Inc.) posts a D grade (45/100 RQD, P/E N/A, ROIC —, cap $131.6M). Among the 5-stock peer group, SPRB leads on earnings multiple (N/A) while SPRB leads on capital efficiency (-35.0% ROIC).
🤖 Gideon Ashmere • AI SEC 10-K Forensics (Click for Instant Brief)
What are the biggest fundamental strengths and SEC risk factors for SPRB?
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Per SPRB's SEC EDGAR XBRL 10-K filing (FY2025, filed 2025-12-31, CIK 0001683553), Spruce Biosciences Inc. generated $102.2M in revenue (+1981.8% YoY), -$39.0M in net income, and -$33.3M in free cash flow against $53.0M in total assets and $0 in total debt. Key quantitative strengths: Established market leader in Health Care with deep daily trading liquidity. Primary risk factors monitored: Company executives have done more routine share selling than personal cash buying lately. Institutional options positioning shows a 50% call / 50% put premium split.
Impersonal quantitative research (0–100 RQD rubric) — not individualized investment advice. Past performance does not guarantee future results. Full Disclaimer
Altman Z-Score 0.20 (DISTRESS RISK (<1.8)) • Piotroski F-Score 4/9
FRED Regime × Technicals: 7% of 52W Range • RSI-14 at 52.1 (NEUTRAL RANGE)
Capital intensity & 0% operating margin leave 16 pts on the table
⚔️ Adversarial Opposing Case: What Could Spark a SPRB Turnaround Squeeze
While SPRB currently carries a cautious 34/100 (E) rating due to Cash Engine Quality (4/20), shorts face asymmetric squeeze risk if free cash flow inflects or management executes accretive buybacks.
Established market leader in Health Care with deep daily trading liquidity.
Options & Short-Covering Gamma: Reclaiming the 50-day SMA ($49.65) and Max Pain ($46.78) forces dealer call-delta covering toward $135.45.
Forensic Repair Trigger: Halting share dilution (Dilution Drag (+1.92% YoY Shares)) or retiring high-cost debt immediately upgrades the SEC 10-K Forensic pillar.
Why SPRB Stock dropped -3.97% Today — RQD Quant Desk Flash
Spruce Biosciences Inc. (SPRB) dropped -3.97% to $44.55, trading at 7% of its 52-week range ($38.06 – $129). Stretched risk/reward at current multiples (-35% return on capital) under elevated 10-year interest-rate pressure.
- ▸Technical Tape: Trading at 7% of its 52-week range ($38.06 – $129) with RSI-14 at 52.1 (NEUTRAL RANGE).
- ▸Volatility Profile: Historical 20-day realized swing band of ±12.2% around $44.55 (no active unusual options sweep snapshot on file).
- ▸Fundamental Anchor: Roarable E (Strong Sell) backed by 52% gross margin and $0 annual free cash flow.
Investing.com report covering Spruce Biosciences Inc. (SPRB) market action, institutional positioning, and fundamental catalysts.
Yahoo Finance report covering Spruce Biosciences Inc. (SPRB) market action, institutional positioning, and fundamental catalysts.
https://www.siam.in/ report covering Spruce Biosciences Inc. (SPRB) market action, institutional positioning, and fundamental catalysts.
Yahoo! Finance Canada report covering Spruce Biosciences Inc. (SPRB) market action, institutional positioning, and fundamental catalysts.
https://www.dars.gov.et/ report covering Spruce Biosciences Inc. (SPRB) market action, institutional positioning, and fundamental catalysts.
SOUTH SAN FRANCISCO, Calif., November 02, 2026--Spruce Biosciences, Inc. (Nasdaq: SPRB), a late-stage biopharmaceutical company focused on developing and commercializing novel therapies for neurological disorders with si
Red-Light Warning Desk: Spotting SEC Cash-Flow & Dilution Risks Before Downgrades (Featuring SPRB)
- ✓Walkthrough of SPRB's RQD Radar, SEC cash-conversion gap & downside invalidation levels
- ✓3 asymmetric Bear/Hedge frameworks when 10-year Treasury yields stay elevated
- ✓Includes nightly RQD rating-change & forensic signal email alerts on your tracked stocks
SPRB Dilution Monitor, Expectations Hurdle, Butterfly Connections & Policy Exposure
Multi-year comparable XBRL diluted share count not disclosed (ETF or recent listing).
vs. +1981.8% actual YoY revenue growth (assuming 9.25% cost of equity & 16.5x terminal multiple).
No active Ellis Vennor swing setup published on SPRB today. View full Setup Ledger →
No direct multi-tier Butterfly edges indexed yet for SPRB. Explore sector supply chains on /butterfly.
📊 Quantitative Sector Peer Comparison, SEC Filing Delta & Investment FAQ (SPRB)
1. Head-to-Head Health Care Peer Comparison (SPRB vs. KZIA, OGI, CATX, NBP)
Industry: Biotechnology: Pharmaceutical Preparations (489 Tracked Issuers)Across 1015 tracked Health Care securities in the Roarable RQD universe, Spruce Biosciences Inc. (SPRB) ranks #633 by composite RQD confidence (34/100, grade E) and #619 by equity capitalization ($133.3M). Within this direct 5-issuer industry benchmark cohort, SPRB leads on earnings valuation at N/A trailing P/E, while SPRB leads on capital efficiency and profitability with -35.0% ROIC and — gross margin. KZIA currently holds the highest overall quantitative score in the immediate peer group at 47/100 (D) compared with SPRB at 34/100 (E).
| Ticker / Company | Roarable Grade | RQD Score | Trailing P/E | Gross Margin | ROIC | 1D Change | Market Cap | Head-to-Head |
|---|---|---|---|---|---|---|---|---|
| SPRB
ACTIVE
Spruce Biosciences Inc. | E | 34/100 | — | — | -35.0% | -3.97% | $133.3M | Benchmark Subject |
| KZIA Kazia Therapeutics Limited | D | 47/100 | — | — | — | -5.65% | $132.2M | /kzia-vs-sprb → |
| OGI Organigram Global Inc. | D | 45/100 | — | — | — | +3.43% | $131.6M | /ogi-vs-sprb → |
| CATX Perspective Therapeutics Inc. | E | 33/100 | — | — | -35.0% | -9.56% | $131.3M | /catx-vs-sprb → |
| NBP NovaBridge Biosciences | E | 34/100 | — | — | -35.0% | -10.46% | $137.9M | /nbp-vs-sprb → |
2. Multi-Year SEC XBRL Revenue, Cash Flow & Balance-Sheet Trajectory (FY2023–FY2025)
SEC EDGAR 10-K • FILED 2025-12-31 • CIK 0001683553 ↗In its most recent audited fiscal period (FY2025, filed 2025-12-31), Spruce Biosciences Inc. (SPRB) reported GAAP revenue of $102.2M (+1981.8% vs. FY2024 revenue of $4.9M , and +913.3% cumulative change since FY2023) , GAAP net income of -$39.0M, operating cash flow of -$33.3M, and free cash flow of -$33.3M (+40.4% YoY). On the balance sheet, SPRB closed FY2025 with $53.0M in total assets against $0 in total debt (Altman Z-Score: 0.20, Piotroski F-Score: 4/9).
| Fiscal Period | Filing Date | Revenue | Net Income | Operating Cash Flow | Free Cash Flow | Total Assets | Total Debt |
|---|---|---|---|---|---|---|---|
| FY2025 (FY) | 2025-12-31 | $102.2M | -$39.0M | -$33.3M | -$33.3M | $53.0M | $0 |
| FY2024 (FY) | 2024-12-31 | $4.9M | -$53.0M | -$56.0M | -$56.0M | $45.2M | $124.0K |
| FY2023 (FY) | 2023-12-31 | $10.1M | -$47.9M | -$33.3M | -$33.3M | — | — |
3. SPRB Data-Verified Investor FAQ (RQD Rating, Sector Peers, SEC Forensics & Technicals)
✓ SCHEMA.ORG FAQPAGE JSON-LD ENABLEDIs SPRB stock a Buy, Hold, or Sell right now according to Roarable's RQD model?
As of 2026-11-03, Spruce Biosciences Inc. (NASDAQ: SPRB) is rated E (Strong Sell / SELL) by Roarable's 5-pillar RQD engine with a composite confidence score of 34/100 at a spot price of $44.55 (-3.97% 1D, market cap $133.3M). Pillar breakdown: Fundamental Cash Engine 4/20, Institutional 13F & Options Flow 5/20, SEC Balance-Sheet Forensics 10/20, FRED Macro Regime Fit 10/20, and Executive Insider Alignment 5/20. Across 1015 tracked Health Care issuers, SPRB ranks #633 in composite RQD confidence.
How does SPRB compare to KZIA and OGI in the Health Care sector?
Within the Health Care sector (Biotechnology: Pharmaceutical Preparations), SPRB carries a Roarable E (34/100 RQD), trailing P/E of N/A, gross margin of —, and ROIC of -35.0%. By comparison, KZIA (Kazia Therapeutics Limited) holds a D grade (47/100 RQD, P/E N/A, ROIC —, cap $132.2M) and OGI (Organigram Global Inc.) posts a D grade (45/100 RQD, P/E N/A, ROIC —, cap $131.6M). Among the 5-stock peer group, SPRB leads on earnings multiple (N/A) while SPRB leads on capital efficiency (-35.0% ROIC).
What are the biggest fundamental strengths and SEC risk factors for SPRB?
Per SPRB's SEC EDGAR XBRL 10-K filing (FY2025, filed 2025-12-31, CIK 0001683553), Spruce Biosciences Inc. generated $102.2M in revenue (+1981.8% YoY), -$39.0M in net income, and -$33.3M in free cash flow against $53.0M in total assets and $0 in total debt. Key quantitative strengths: Established market leader in Health Care with deep daily trading liquidity. Primary risk factors monitored: Company executives have done more routine share selling than personal cash buying lately. Institutional options positioning shows a 50% call / 50% put premium split.
Where is SPRB trading relative to its 50-day, 200-day, and 52-week technical levels?
SPRB last traded at $44.55 (-3.97% on volume of 90,551 shares), positioning the stock -10.27% below its 50-day simple moving average ($49.65) and -19.73% below its 200-day simple moving average ($55.50). Across its 52-week range of $38.06 to $129.00, SPRB sits at the 7.1% percentile with a 14-day RSI of 52.1 (NEUTRAL RANGE) and an implied next-earnings move of ±12.2% ($39.11 to $49.99).
SPRB — Spruce Biosciences Inc.: What the Facts Mean to a Prospective Investor
1. Roarable Rating Brief: What This Means to a Prospective Investor
Spruce Biosciences Inc. (SPRB) earns a live Roarable RQD composite score of 34/100, corresponding to a E letter grade (Roarable Strong Sell) at a spot price of $44.55 (-3.97% 1D, market capitalization $133.3M).
- Fundamental Cash Engine (4/20): Anchored by return on invested capital (ROIC) of -35.0%, gross margin of —, operating margin of —, and free cash flow yield of -24.77%.
- Whale 13F & Options Flow (5/20) + Insider Conviction (5/20): Tracks institutional 13F accumulation, CBOE options call/put positioning, and SEC Form 4 / Congressional PTR filings.
- Macro Regime Fit (10/20) + Forensic Balance Sheet (10/20): Incorporates a 1.00x equity beta, Altman Z-Score of 0.20, Piotroski F-Score of 4/9, and Debt/Equity of 0.00x.
2. Business Model, Unit Margins & SEC Financial Trajectory
Spruce Biosciences Inc. (SPRB) is a NASDAQ-listed company in the Health Care sector, operating in the Biotechnology: Pharmaceutical Preparations industry. Per the recent news catalysts, the company is associated with MPS IIIB natural history data, indicating a focus on rare disease research.
In its latest audited SEC EDGAR 10-K filing for FY2025 (filed 2025-12-31), Spruce Biosciences Inc. (SPRB) reported $102.2M in annual revenue (up from $4.9M in FY2024, +1981.8% YoY) and -$39.0M in GAAP net income. Over the multi-year SEC filing window from FY2023 ($10.1M revenue, -$47.9M net income) through FY2025, SPRB scaled operating cash flow to -$33.3M and free cash flow to -$33.3M, backed by $53.0M in total assets against $0 in total debt.
3. Institutional Bull vs. Bear Thesis & Valuation Tradeoff
- 🐂 Primary Bull Case (E • RQD 34/100): Established market leader in Health Care with deep daily trading liquidity. Free cash flow yield of -24.77% and institutional whale pillar of 5/20. With Fundamental Cash Engine at 4/20 and Institutional Whale Flow at 5/20, sustained execution supports upside toward the upper end of the $38.06 – $129.00 52-week range.
- 🐻 Primary Bear Case & Valuation Risk: Company executives have done more routine share selling than personal cash buying lately. Investors must weigh current valuation against — operating margins and a 1.00x macro beta.
4. 2nd-Order Butterfly Ripples & Key Questions to Watch
No upstream or downstream dependencies, sector correlations, or proprietary signal links are recorded. Upstream/downstream dependency mapping: — Sector correlation data: — Second-order bottlenecks: — Investors should note that the absence of mapped links means this analysis cannot identify ripple effects from peers or suppliers.
- Key Question #1: Can SPRB sustain or expand its — operating margin and -35.0% ROIC against Biotechnology: Pharmaceutical Preparations peers over the next 4 quarters?
- Key Question #2: Following FY2025 revenue of $102.2M and free cash flow of -$33.3M, how will capital allocation balance growth reinvestment against $0 in total debt?
- Key Question #3: How sensitive is SPRB's equity valuation to Health Care capital spending cycles and macro interest-rate shifts (Beta 1.00x)?
SPRB Live News Feed, Press Releases & Catalyst Wire
Real-time company headlines, analyst actions, and sector developments for Spruce Biosciences Inc. (SPRB) • Click "Debate This Headline" to argue it in the Roar Pit below
Yahoo Finance report covering Spruce Biosciences Inc. (SPRB) market action, institutional positioning, and fundamental catalysts.
Investing.com report covering Spruce Biosciences Inc. (SPRB) market action, institutional positioning, and fundamental catalysts.
Yahoo Finance report covering Spruce Biosciences Inc. (SPRB) market action, institutional positioning, and fundamental catalysts.
https://www.siam.in/ report covering Spruce Biosciences Inc. (SPRB) market action, institutional positioning, and fundamental catalysts.
Yahoo! Finance Canada report covering Spruce Biosciences Inc. (SPRB) market action, institutional positioning, and fundamental catalysts.
https://www.dars.gov.et/ report covering Spruce Biosciences Inc. (SPRB) market action, institutional positioning, and fundamental catalysts.
SOUTH SAN FRANCISCO, Calif., November 02, 2026--Spruce Biosciences, Inc. (Nasdaq: SPRB), a late-stage biopharmaceutical company focused on developing and commercializing novel therapies for neurological disorders with si
SPRB Bull vs. Bear Conversation Board — What's Your Call at $44.55?
Net cash of $48.9M against $0.0M debt in FY 2025 gives the company a balance sheet with no reported debt burden.
Picked up a starter position in SPRB in my $100K Virtual Cash book at $46.39. Net cash of $48.9M against $0.0M debt in FY 2025 gives the company a balance sheet with no reported debt burden.. Trading inside a $38.06–$129.00 52-week range with -24.77% FCF yield gives solid downside support if Biotechnology: Pharmaceutical Preparations multiples expand this quarter.
@MultipleCompression Shorting a 5/20 institutional whale-flow stock at $46.39 is dangerous when funds are rotating into Health Care.
Revenue fell from $10.1M to $0.0M over two years while FCF remained negative at -$33.3M, with an Altman Z-Score of 0.2.
Here is the bear case nobody on the bull side wants to address on SPRB: Revenue fell from $10.1M to $0.0M over two years while FCF remained negative at -$33.3M, with an Altman Z-Score of 0.2.. At current EV/EBITDA multiples, even a small guidance miss in Biotechnology: Pharmaceutical Preparations triggers a 12-15% air pocket.