Yahoo Finance report covering Amylyx Pharmaceuticals Inc. (AMLX) market action, institutional positioning, and fundamental catalysts.
Why AMLX Stock advanced +0.63% Today — RQD Quant Desk Flash
Amylyx Pharmaceuticals Inc. (AMLX) carries a Roarable Rating of D- (Sell) with 39/100 RQD Confidence due to weak cash-flow efficiency and sensitivity to current interest rates. Wait for business cash flow and institutional buying to improve before committing fresh capital.
🤖 Mara Quenwick • AI Quant Lead (Click for Instant Brief)
Is AMLX stock a Buy, Hold, or Sell right now according to Roarable's RQD model?
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As of 2026-11-02, Amylyx Pharmaceuticals Inc. (NASDAQ: AMLX) is rated D- (Sell / SELL) by Roarable's 5-pillar RQD engine with a composite confidence score of 39/100 at a spot price of $28.86 (+0.63% 1D, market cap $3.60B). Pillar breakdown: Fundamental Cash Engine 6/20, Institutional 13F & Options Flow 10/20, Executive Insider Alignment 10/20, FRED Macro Regime Fit 10/20, and SEC Balance-Sheet Forensics 3/20. Across 1016 tracked Health Care issuers, AMLX ranks #543 in composite RQD confidence.
🤖 Ellis Vennor • AI Peer & Flow Quant (Click for Instant Brief)
How does AMLX compare to ACAD and OGN in the Health Care sector?
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Within the Health Care sector (Biotechnology: Pharmaceutical Preparations), AMLX carries a Roarable D- (39/100 RQD), trailing P/E of N/A, gross margin of —, and ROIC of -35.0%. By comparison, ACAD (ACADIA Pharmaceuticals Inc.) holds a D grade (50/100 RQD, P/E 9.1x, ROIC 7.9%, cap $3.58B) and OGN (Organon & Co.) posts a B- grade (70/100 RQD, P/E 19.4x, ROIC 24.9%, cap $3.63B). Among the 5-stock peer group, ACAD leads on earnings multiple (9.1x) while OGN leads on capital efficiency (24.9% ROIC).
🤖 Gideon Ashmere • AI SEC 10-K Forensics (Click for Instant Brief)
What are the biggest fundamental strengths and SEC risk factors for AMLX?
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Per AMLX's SEC EDGAR XBRL 10-K filing (FY2025, filed 2025-12-31, CIK 0001658551), Amylyx Pharmaceuticals Inc. generated $0 in revenue (-100.0% YoY), -$144.7M in net income, and -$123.5M in free cash flow against $332.6M in total assets and $0 in total debt. Key quantitative strengths: Established market leader in Health Care with deep daily trading liquidity.. Primary risk factors monitored: Company executives have done more routine share selling than personal cash buying lately.. Institutional options positioning shows a 50% call / 50% put premium split.
Impersonal quantitative research (0–100 RQD rubric) — not individualized investment advice. Past performance does not guarantee future results. Full Disclaimer
20D Institutional Volume Accumulation (±10.1% realized swing band)
Altman Z-Score 3.80 (FORTRESS SAFE (>3.0)) • Piotroski F-Score 3/9
Dilution Drag (+2.48% YoY Shares) & executive Form 4 sales trim 16 pts from alignment
⚔️ Adversarial Opposing Case: What Could Spark a AMLX Turnaround Squeeze
While AMLX currently carries a cautious 39/100 (D-) rating due to Insider Conviction & Share Dilution (4/20), shorts face asymmetric squeeze risk if free cash flow inflects or management executes accretive buybacks.
Established market leader in Health Care with deep daily trading liquidity.
Options & Short-Covering Gamma: Reclaiming the 50-day SMA ($30.69) and Max Pain ($30.30) forces dealer call-delta covering toward $43.20.
Forensic Repair Trigger: Halting share dilution (Dilution Drag (+2.48% YoY Shares)) or retiring high-cost debt immediately upgrades the SEC 10-K Forensic pillar.
Why AMLX Stock advanced +0.63% Today — RQD Quant Desk Flash
Amylyx Pharmaceuticals Inc. (AMLX) advanced +0.63% to $28.86, trading at 59% of its 52-week range ($10.83 – $41.14). Stretched risk/reward at current multiples (-35% return on capital) under elevated 10-year interest-rate pressure.
- ▸Technical Tape: Trading at 59% of its 52-week range ($10.83 – $41.14) with RSI-14 at 50.8 (NEUTRAL RANGE).
- ▸Volatility Profile: Historical 20-day realized swing band of ±10.1% around $28.86 (no active unusual options sweep snapshot on file).
- ▸Fundamental Anchor: Roarable D- (Sell) backed by 52% gross margin and $0 annual free cash flow.
TradingView report covering Amylyx Pharmaceuticals Inc. (AMLX) market action, institutional positioning, and fundamental catalysts.
Simply Wall St report covering Amylyx Pharmaceuticals Inc. (AMLX) market action, institutional positioning, and fundamental catalysts.
Stock Titan report covering Amylyx Pharmaceuticals Inc. (AMLX) market action, institutional positioning, and fundamental catalysts.
Benzinga report covering Amylyx Pharmaceuticals Inc. (AMLX) market action, institutional positioning, and fundamental catalysts.
TradingView report covering Amylyx Pharmaceuticals Inc. (AMLX) market action, institutional positioning, and fundamental catalysts.
MarketBeat report covering Amylyx Pharmaceuticals Inc. (AMLX) market action, institutional positioning, and fundamental catalysts.
Simply Wall St report covering Amylyx Pharmaceuticals Inc. (AMLX) market action, institutional positioning, and fundamental catalysts.
For questions about this article or underlying research, email help@trefis.com.
Citigroup analyst Geoff Meacham maintains Amylyx Pharmaceuticals (NASDAQ:AMLX) with a Buy and raises the price target from $32 to $39.
Red-Light Warning Desk: Spotting SEC Cash-Flow & Dilution Risks Before Downgrades (Featuring AMLX)
- ✓Walkthrough of AMLX's RQD Radar, SEC cash-conversion gap & downside invalidation levels
- ✓3 asymmetric Bear/Hedge frameworks when 10-year Treasury yields stay elevated
- ✓Includes nightly RQD rating-change & forensic signal email alerts on your tracked stocks
AMLX Dilution Monitor, Expectations Hurdle, Butterfly Connections & Policy Exposure
Multi-year comparable XBRL diluted share count not disclosed (ETF or recent listing).
vs. +6.0% actual YoY revenue growth (assuming 9.25% cost of equity & 16.5x terminal multiple).
No active Ellis Vennor swing setup published on AMLX today. View full Setup Ledger →
No direct multi-tier Butterfly edges indexed yet for AMLX. Explore sector supply chains on /butterfly.
📊 Quantitative Sector Peer Comparison, SEC Filing Delta & Investment FAQ (AMLX)
1. Head-to-Head Health Care Peer Comparison (AMLX vs. ACAD, OGN, XENE, IRON)
Industry: Biotechnology: Pharmaceutical Preparations (489 Tracked Issuers)Across 1016 tracked Health Care securities in the Roarable RQD universe, Amylyx Pharmaceuticals Inc. (AMLX) ranks #543 by composite RQD confidence (39/100, grade D-) and #192 by equity capitalization ($3.60B). Within this direct 5-issuer industry benchmark cohort, ACAD leads on earnings valuation at 9.1x trailing P/E, while OGN leads on capital efficiency and profitability with 24.9% ROIC and 53.3% gross margin. OGN currently holds the highest overall quantitative score in the immediate peer group at 70/100 (B-) compared with AMLX at 39/100 (D-).
| Ticker / Company | Roarable Grade | RQD Score | Trailing P/E | Gross Margin | ROIC | 1D Change | Market Cap | Head-to-Head |
|---|---|---|---|---|---|---|---|---|
| AMLX
ACTIVE
Amylyx Pharmaceuticals Inc. | D- | 39/100 | — | — | -35.0% | +0.63% | $3.60B | Benchmark Subject |
| ACAD ACADIA Pharmaceuticals Inc. | D | 50/100 | 9.1x | 91.7% | 7.9% | -0.82% | $3.58B | /acad-vs-amlx → |
| OGN Organon & Co. | B- | 70/100 | 19.4x | 53.3% | 24.9% | +0.22% | $3.63B | /ogn-vs-amlx → |
| XENE Xenon Pharmaceuticals Inc. | D- | 37/100 | — | — | -35.0% | -0.35% | $3.64B | /xene-vs-amlx → |
| IRON Disc Medicine Inc. | D+ | 54/100 | — | — | -27.5% | -2.41% | $3.68B | /iron-vs-amlx → |
2. Multi-Year SEC XBRL Revenue, Cash Flow & Balance-Sheet Trajectory (FY2023–FY2025)
SEC EDGAR 10-K • FILED 2025-12-31 • CIK 0001658551In its most recent audited fiscal period (FY2025, filed 2025-12-31), Amylyx Pharmaceuticals Inc. (AMLX) reported GAAP revenue of $0 (-100.0% vs. FY2024 revenue of $87.4M , and -100.0% cumulative change since FY2023) , GAAP net income of -$144.7M, operating cash flow of -$123.3M, and free cash flow of -$123.5M (+26.4% YoY). On the balance sheet, AMLX closed FY2025 with $332.6M in total assets against $0 in total debt (Altman Z-Score: N/A, Piotroski F-Score: 3/9).
| Fiscal Period | Filing Date | Revenue | Net Income | Operating Cash Flow | Free Cash Flow | Total Assets | Total Debt |
|---|---|---|---|---|---|---|---|
| FY2025 (FY) | 2025-12-31 | $0 | -$144.7M | -$123.3M | -$123.5M | $332.6M | — |
| FY2024 (FY) | 2024-12-31 | $87.4M | -$301.7M | -$167.6M | -$167.8M | $193.6M | — |
| FY2023 (FY) | 2023-12-31 | $380.8M | $49.3M | $11.9M | $11.9M | — | — |
3. AMLX Data-Verified Investor FAQ (RQD Rating, Sector Peers, SEC Forensics & Technicals)
✓ SCHEMA.ORG FAQPAGE JSON-LD ENABLEDIs AMLX stock a Buy, Hold, or Sell right now according to Roarable's RQD model?
As of 2026-11-02, Amylyx Pharmaceuticals Inc. (NASDAQ: AMLX) is rated D- (Sell / SELL) by Roarable's 5-pillar RQD engine with a composite confidence score of 39/100 at a spot price of $28.86 (+0.63% 1D, market cap $3.60B). Pillar breakdown: Fundamental Cash Engine 6/20, Institutional 13F & Options Flow 10/20, Executive Insider Alignment 10/20, FRED Macro Regime Fit 10/20, and SEC Balance-Sheet Forensics 3/20. Across 1016 tracked Health Care issuers, AMLX ranks #543 in composite RQD confidence.
How does AMLX compare to ACAD and OGN in the Health Care sector?
Within the Health Care sector (Biotechnology: Pharmaceutical Preparations), AMLX carries a Roarable D- (39/100 RQD), trailing P/E of N/A, gross margin of —, and ROIC of -35.0%. By comparison, ACAD (ACADIA Pharmaceuticals Inc.) holds a D grade (50/100 RQD, P/E 9.1x, ROIC 7.9%, cap $3.58B) and OGN (Organon & Co.) posts a B- grade (70/100 RQD, P/E 19.4x, ROIC 24.9%, cap $3.63B). Among the 5-stock peer group, ACAD leads on earnings multiple (9.1x) while OGN leads on capital efficiency (24.9% ROIC).
What are the biggest fundamental strengths and SEC risk factors for AMLX?
Per AMLX's SEC EDGAR XBRL 10-K filing (FY2025, filed 2025-12-31, CIK 0001658551), Amylyx Pharmaceuticals Inc. generated $0 in revenue (-100.0% YoY), -$144.7M in net income, and -$123.5M in free cash flow against $332.6M in total assets and $0 in total debt. Key quantitative strengths: Established market leader in Health Care with deep daily trading liquidity.. Primary risk factors monitored: Company executives have done more routine share selling than personal cash buying lately.. Institutional options positioning shows a 50% call / 50% put premium split.
Where is AMLX trading relative to its 50-day, 200-day, and 52-week technical levels?
AMLX last traded at $28.86 (+0.63% on volume of 989,547 shares), positioning the stock -5.96% below its 50-day simple moving average ($30.69) and +43.23% above its 200-day simple moving average ($20.15). Across its 52-week range of $10.83 to $41.14, AMLX sits at the 59.5% percentile with a 14-day RSI of 50.8 (NEUTRAL RANGE) and an implied next-earnings move of ±10.1% ($25.95 to $31.77).
AMLX Investor FAQ & Complete 8-Part Research Index
100% OPEN ACCESS • SEC EDGAR × CBOE × FREDWhy is AMLX stock moving today?
Why AMLX Stock advanced +0.63% Today — RQD Quant Desk Flash. Stretched risk/reward at current multiples (-35% return on capital) under elevated 10-year interest-rate pressure.
AMLX — Amylyx Pharmaceuticals Inc.: What the Facts Mean to a Prospective Investor
Roarable Rating Brief: What This Means to a Prospective Investor
Per the Roarable RQD rating, AMLX scores 39 out of 100 and carries a letter grade of D-, with the verdict label "Roarable Sell — Vulnerable Balance Sheet & Flow." The five pillars break down as follows:
- Fundamental Cash Engine: 6 / 20. This is the weakest contributor. The rating cites ROIC of -35% and an FCF yield of -3.43%, indicating that the business is currently consuming capital rather than generating it relative to its market value.
- Whale 13F Flow: 10 / 20. Institutional accumulation and options positioning are rated at a mid-range level. This is neutral-to-modestly supportive and does not by itself offset the fundamental weakness.
- Insider Conviction: 3 / 20. The SEC Form 4 and Congressional PTR cluster flow is rated very low, which suggests limited insider-level confidence signals in the data.
- Macro Regime Fit: 10 / 20. Beta is 1.0 and the rating notes sector sensitivity. The stock's market sensitivity is average, so it neither amplifies nor dampens broad market moves on this measure.
- Forensic Balance Sheet: 10 / 20. Per the rating, Altman Z is 2.5, Piotroski F is 3/9, and Debt/Equity is 0.5. These readings point to moderate balance-sheet strength on the Altman measure but weak operating-quality signals on Piotroski.
For a prospective investor evaluating the stock today, the rating's implication is that the cash-generation and insider-signal pillars are the primary drags, while institutional flow and balance-sheet metrics are only middling. Upside drivers would need to come from a turn in cash generation, which the current ROIC and FCF yield do not yet show. Valuation tradeoffs are difficult to assess directly because P/E and EV/EBITDA are unavailable in the source data, and the company reports negative earnings in the periods provided. The rating is a quantitative screen and is presented here for educational purposes, not as personalized financial advice.
Financial Trend
| Period | Revenue | Operating Income | Net Income | EPS | FCF | Cash | Debt |
|---|---|---|---|---|---|---|---|
| FY 2025 | $0.0M | $-153.3M | $-144.7M | N/A | $-123.5M | $226.7M | N/A |
| FY 2024 | $87.4M | $-314.7M | $-301.7M | N/A | $-167.8M | $77.4M | N/A |
| FY 2023 | $380.8M | $38.8M | $49.3M | N/A | $11.9M | N/A | N/A |
Per the SEC financials, operating and net results moved from positive in FY 2023 to substantial losses in both FY 2024 and FY 2025. Margins are reported as 0% for gross, operating, and net in the market data. Per the Roarable RQD rating, ROIC is -35%, and the Altman Z-Score is 2.5 and the Piotroski F-Score is 3/9. Reported cash rose from $77.4M to $226.7M between FY 2024 and FY 2025, and debt is marked N/A in the source data.
Recent Catalysts & News Wire Analysis
Per the news feed, the headlines include a Yahoo Finance report on the stock, a TradingView estimates item, a Simply Wall St forecast item, and a Stock Titan notice that a live call will cover third-quarter results on Nov. 5 at 8 a.m. ET. A Benzinga item references a Q2 2026 earnings call transcript. A TradingView item reports a 12-month price target raised to $43, which the headline states implies 59% upside. The news items are labeled as catalysts or market wire by the feed, with the price-target and Yahoo items flagged green.
Risk watch items per the source data: the upcoming third-quarter results call, and the reported losses and negative FCF in the financial trend. Per the Butterfly Supply-Chain Graph, the supply-chain value is NONE, there are no butterfly links, and there are no proprietary signals. Not available in source data for any additional proprietary signal.
Open Questions
- What are the company's specific revenue sources after FY 2023, given that reported revenue declined to $0.0M in FY 2025?
- What is the reason for the change in reported debt, which is marked N/A across all periods?
- What are the drivers of the increase in cash from $77.4M to $226.7M, and do they reflect operating or financing activity?
- What is the outcome of the third-quarter results call scheduled for Nov. 5?
- What are the EPS, P/E, and EV/EBITDA values, which are not available in the source data?
AMLX Live News Feed, Press Releases & Catalyst Wire
Real-time company headlines, analyst actions, and sector developments for Amylyx Pharmaceuticals Inc. (AMLX) • Click "Debate This Headline" to argue it in the Roar Pit below
Yahoo Finance report covering Amylyx Pharmaceuticals Inc. (AMLX) market action, institutional positioning, and fundamental catalysts.
TradingView report covering Amylyx Pharmaceuticals Inc. (AMLX) market action, institutional positioning, and fundamental catalysts.
Simply Wall St report covering Amylyx Pharmaceuticals Inc. (AMLX) market action, institutional positioning, and fundamental catalysts.
Stock Titan report covering Amylyx Pharmaceuticals Inc. (AMLX) market action, institutional positioning, and fundamental catalysts.
Benzinga report covering Amylyx Pharmaceuticals Inc. (AMLX) market action, institutional positioning, and fundamental catalysts.
TradingView report covering Amylyx Pharmaceuticals Inc. (AMLX) market action, institutional positioning, and fundamental catalysts.
MarketBeat report covering Amylyx Pharmaceuticals Inc. (AMLX) market action, institutional positioning, and fundamental catalysts.
Simply Wall St report covering Amylyx Pharmaceuticals Inc. (AMLX) market action, institutional positioning, and fundamental catalysts.
AMLX Bull vs. Bear Conversation Board — What's Your Call at $28.86?
🔥 Official Bull vs. Bear Debate: Is AMLX (D- • RQD 39/100) a Buy at $28.68?
Welcome to the AMLX (Amylyx Pharmaceuticals Inc.) Roar Pit. Current RQD Composite is 39/100 (Roarable Sell — Vulnerable Balance Sheet & Flow) in Biotechnology: Pharmaceutical Preparations. Bulls point to operating leverage and sector positioning, while bears focus on macro rate sensitivity and margin execution. Pick your side (🐂 Bull or 🐻 Bear) and drop your price target below.
Pump the brakes on AMLX — check the valuation vs. margin headwinds
Everyone in here is repeating the bull case on AMLX, but look at what you are paying: current EV/EBITDA multiples with tightening sector spreads. Unless Amylyx Pharmaceuticals Inc. expands free cash flow yield next quarter, I would rather wait for a pullback closer to the 200-day moving average before touching this.
AMLX cash flow & RQD setup is being underpriced by the Street here
Looking at the 5-pillar RQD breakdown on AMLX, the market is fixating on short-term headline noise in Biotechnology: Pharmaceutical Preparations and ignoring the balance sheet and cash flow trajectory. At $28.68 (52-wk range $10.83 - $41.14), any beat on forward guidance forces shorts and underweight funds to chase.