Investing.com report covering LeonaBio Inc. (LONA) market action, institutional positioning, and fundamental catalysts.
Why LONA Stock advanced +0.61% Today — RQD Quant Desk Flash
LeonaBio Inc. (LONA) carries a Roarable Rating of D- (Sell) with 35/100 RQD Confidence due to weak cash-flow efficiency and sensitivity to current interest rates. Wait for business cash flow and institutional buying to improve before committing fresh capital.
🤖 Mara Quenwick • AI Quant Lead (Click for Instant Brief)
Is LONA stock a Buy, Hold, or Sell right now according to Roarable's RQD model?
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As of 2026-11-03, LeonaBio Inc. (NASDAQ: LONA) is rated D- (Sell / SELL) by Roarable's 5-pillar RQD engine with a composite confidence score of 35/100 at a spot price of $4.94 (+0.61% 1D, market cap $46.5M). Pillar breakdown: Fundamental Cash Engine 9/20, Institutional 13F & Options Flow 3/20, Executive Insider Alignment 10/20, FRED Macro Regime Fit 8/20, and SEC Balance-Sheet Forensics 5/20. Across 1016 tracked Health Care issuers, LONA ranks #603 in composite RQD confidence.
🤖 Ellis Vennor • AI Peer & Flow Quant (Click for Instant Brief)
How does LONA compare to IMA and TIL in the Health Care sector?
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Within the Health Care sector (Biotechnology: Biological Products (No Diagnostic Substances)), LONA carries a Roarable D- (35/100 RQD), trailing P/E of N/A, gross margin of —, and ROIC of -35.0%. By comparison, IMA (ImageneBio Inc.) holds a E grade (19/100 RQD, P/E N/A, ROIC -35.0%, cap $46.5M) and TIL (Instil Bio Inc.) posts a D- grade (39/100 RQD, P/E N/A, ROIC -35.0%, cap $46.1M). Among the 5-stock peer group, LONA leads on earnings multiple (N/A) while LONA leads on capital efficiency (-35.0% ROIC).
🤖 Gideon Ashmere • AI SEC 10-K Forensics (Click for Instant Brief)
What are the biggest fundamental strengths and SEC risk factors for LONA?
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Per LONA's SEC EDGAR XBRL 10-K filing (FY2025, filed 2025-12-31, CIK 0001620463), LeonaBio Inc. generated $0 in revenue, -$106.0M in net income, and -$45.7M in free cash flow against $92.2M in total assets and $0 in total debt. Key quantitative strengths: Established market leader in Health Care with deep daily trading liquidity.. Primary risk factors monitored: Company executives have done more routine share selling than personal cash buying lately.. Institutional options positioning shows a 50% call / 50% put premium split.
Impersonal quantitative research (0–100 RQD rubric) — not individualized investment advice. Past performance does not guarantee future results. Full Disclaimer
Altman Z-Score 3.80 (FORTRESS SAFE (>3.0)) • Piotroski F-Score 2/9
SEC XBRL FY 2025 (10-K): 0% FCF Margin ($0 FCF) & 52% Gross Margin
Put hedging (50% put share) caps near-term gamma upside (-16 pts vs max)
⚔️ Adversarial Opposing Case: What Could Spark a LONA Turnaround Squeeze
While LONA currently carries a cautious 35/100 (D-) rating due to Whale & Options Positioning (4/20), shorts face asymmetric squeeze risk if free cash flow inflects or management executes accretive buybacks.
Established market leader in Health Care with deep daily trading liquidity.
Options & Short-Covering Gamma: Reclaiming the 50-day SMA ($5.94) and Max Pain ($5.19) forces dealer call-delta covering toward $14.92.
Forensic Repair Trigger: Halting share dilution (Disciplined Float (+0.72% YoY Shares)) or retiring high-cost debt immediately upgrades the SEC 10-K Forensic pillar.
Why LONA Stock advanced +0.61% Today — RQD Quant Desk Flash
LeonaBio Inc. (LONA) advanced +0.61% to $4.94, trading at 23% of its 52-week range ($2.21 – $14.21). Stretched risk/reward at current multiples (-35% return on capital) under elevated 10-year interest-rate pressure.
- ▸Technical Tape: Trading at 23% of its 52-week range ($2.21 – $14.21) with RSI-14 at 43.9 (NEUTRAL RANGE).
- ▸Volatility Profile: Historical 20-day realized swing band of ±12.5% around $4.94 (no active unusual options sweep snapshot on file).
- ▸Fundamental Anchor: Roarable D- (Sell) backed by 52% gross margin and $0 annual free cash flow.
Stock Titan report covering LeonaBio Inc. (LONA) market action, institutional positioning, and fundamental catalysts.
www.marketscreener.com report covering LeonaBio Inc. (LONA) market action, institutional positioning, and fundamental catalysts.
Stock Titan report covering LeonaBio Inc. (LONA) market action, institutional positioning, and fundamental catalysts.
kalkine.ca report covering LeonaBio Inc. (LONA) market action, institutional positioning, and fundamental catalysts.
Kalkine Media report covering LeonaBio Inc. (LONA) market action, institutional positioning, and fundamental catalysts.
Gainers iSpecimen (NASDAQ:ISPC) stock moved upwards by 16.1% to $0.92 during Thursday's after-market session. The company's market cap stands at $2.2 million. CareDx (NASDAQ:CDNA) stock rose 15.0% to $82.25.
Gainers Profusa (NASDAQ:PFSA) shares moved upwards by 35.4% to $1.15 during Thursday's regular session. Karyopharm Therapeutics (NASDAQ:KPTI) shares increased by 29.12% to $0.55. The company's market cap
Red-Light Warning Desk: Spotting SEC Cash-Flow & Dilution Risks Before Downgrades (Featuring LONA)
- ✓Walkthrough of LONA's RQD Radar, SEC cash-conversion gap & downside invalidation levels
- ✓3 asymmetric Bear/Hedge frameworks when 10-year Treasury yields stay elevated
- ✓Includes nightly RQD rating-change & forensic signal email alerts on your tracked stocks
LONA Dilution Monitor, Expectations Hurdle, Butterfly Connections & Policy Exposure
Multi-year comparable XBRL diluted share count not disclosed (ETF or recent listing).
vs. +6.0% actual YoY revenue growth (assuming 9.25% cost of equity & 16.5x terminal multiple).
No active Ellis Vennor swing setup published on LONA today. View full Setup Ledger →
No direct multi-tier Butterfly edges indexed yet for LONA. Explore sector supply chains on /butterfly.
📊 Quantitative Sector Peer Comparison, SEC Filing Delta & Investment FAQ (LONA)
1. Head-to-Head Health Care Peer Comparison (LONA vs. IMA, TIL, CRBU, INMB)
Industry: Biotechnology: Biological Products (No Diagnostic Substances) (156 Tracked Issuers)Across 1016 tracked Health Care securities in the Roarable RQD universe, LeonaBio Inc. (LONA) ranks #603 by composite RQD confidence (35/100, grade D-) and #754 by equity capitalization ($46.5M). Within this direct 5-issuer industry benchmark cohort, LONA leads on earnings valuation at N/A trailing P/E, while LONA leads on capital efficiency and profitability with -35.0% ROIC and — gross margin. TIL currently holds the highest overall quantitative score in the immediate peer group at 39/100 (D-) compared with LONA at 35/100 (D-).
| Ticker / Company | Roarable Grade | RQD Score | Trailing P/E | Gross Margin | ROIC | 1D Change | Market Cap | Head-to-Head |
|---|---|---|---|---|---|---|---|---|
| LONA
ACTIVE
LeonaBio Inc. | D- | 35/100 | — | — | -35.0% | +0.61% | $46.5M | Benchmark Subject |
| IMA ImageneBio Inc. | E | 19/100 | — | — | -35.0% | +1.24% | $46.5M | /ima-vs-lona → |
| TIL Instil Bio Inc. | D- | 39/100 | — | — | -35.0% | -0.37% | $46.1M | /til-vs-lona → |
| CRBU Caribou Biosciences Inc. | E | 32/100 | — | — | -35.0% | -4.90% | $45.4M | /crbu-vs-lona → |
| INMB INmune Bio Inc. | E | 30/100 | — | — | -35.0% | -9.37% | $44.9M | /inmb-vs-lona → |
2. Multi-Year SEC XBRL Revenue, Cash Flow & Balance-Sheet Trajectory (FY2023–FY2025)
SEC EDGAR 10-K • FILED 2025-12-31 • CIK 0001620463In its most recent audited fiscal period (FY2025, filed 2025-12-31), LeonaBio Inc. (LONA) reported GAAP revenue of $0 (N/A vs. FY2024 revenue of $0 ) , GAAP net income of -$106.0M, operating cash flow of -$45.7M, and free cash flow of -$45.7M (+53.0% YoY). On the balance sheet, LONA closed FY2025 with $92.2M in total assets against $0 in total debt (Altman Z-Score: N/A, Piotroski F-Score: 2/9).
| Fiscal Period | Filing Date | Revenue | Net Income | Operating Cash Flow | Free Cash Flow | Total Assets | Total Debt |
|---|---|---|---|---|---|---|---|
| FY2025 (FY) | 2025-12-31 | $0 | -$106.0M | -$45.7M | -$45.7M | $92.2M | — |
| FY2024 (FY) | 2024-12-31 | $0 | -$97.0M | -$97.2M | -$97.2M | $58.8M | — |
| FY2023 (FY) | 2023-12-31 | $0 | -$117.7M | -$100.8M | -$100.8M | — | — |
3. LONA Data-Verified Investor FAQ (RQD Rating, Sector Peers, SEC Forensics & Technicals)
✓ SCHEMA.ORG FAQPAGE JSON-LD ENABLEDIs LONA stock a Buy, Hold, or Sell right now according to Roarable's RQD model?
As of 2026-11-03, LeonaBio Inc. (NASDAQ: LONA) is rated D- (Sell / SELL) by Roarable's 5-pillar RQD engine with a composite confidence score of 35/100 at a spot price of $4.94 (+0.61% 1D, market cap $46.5M). Pillar breakdown: Fundamental Cash Engine 9/20, Institutional 13F & Options Flow 3/20, Executive Insider Alignment 10/20, FRED Macro Regime Fit 8/20, and SEC Balance-Sheet Forensics 5/20. Across 1016 tracked Health Care issuers, LONA ranks #603 in composite RQD confidence.
How does LONA compare to IMA and TIL in the Health Care sector?
Within the Health Care sector (Biotechnology: Biological Products (No Diagnostic Substances)), LONA carries a Roarable D- (35/100 RQD), trailing P/E of N/A, gross margin of —, and ROIC of -35.0%. By comparison, IMA (ImageneBio Inc.) holds a E grade (19/100 RQD, P/E N/A, ROIC -35.0%, cap $46.5M) and TIL (Instil Bio Inc.) posts a D- grade (39/100 RQD, P/E N/A, ROIC -35.0%, cap $46.1M). Among the 5-stock peer group, LONA leads on earnings multiple (N/A) while LONA leads on capital efficiency (-35.0% ROIC).
What are the biggest fundamental strengths and SEC risk factors for LONA?
Per LONA's SEC EDGAR XBRL 10-K filing (FY2025, filed 2025-12-31, CIK 0001620463), LeonaBio Inc. generated $0 in revenue, -$106.0M in net income, and -$45.7M in free cash flow against $92.2M in total assets and $0 in total debt. Key quantitative strengths: Established market leader in Health Care with deep daily trading liquidity.. Primary risk factors monitored: Company executives have done more routine share selling than personal cash buying lately.. Institutional options positioning shows a 50% call / 50% put premium split.
Where is LONA trading relative to its 50-day, 200-day, and 52-week technical levels?
LONA last traded at $4.94 (+0.61% on volume of 43,072 shares), positioning the stock -16.84% below its 50-day simple moving average ($5.94) and -34.13% below its 200-day simple moving average ($7.50). Across its 52-week range of $2.21 to $14.21, LONA sits at the 22.8% percentile with a 14-day RSI of 43.9 (NEUTRAL RANGE) and an implied next-earnings move of ±12.5% ($4.32 to $5.56).
LONA Investor FAQ & Complete 8-Part Research Index
100% OPEN ACCESS • SEC EDGAR × CBOE × FREDWhy is LONA stock moving today?
Why LONA Stock advanced +0.61% Today — RQD Quant Desk Flash. Stretched risk/reward at current multiples (-35% return on capital) under elevated 10-year interest-rate pressure.
LONA — LeonaBio Inc.: What the Facts Mean to a Prospective Investor
Roarable Rating Brief: What This Means to a Prospective Investor
Per the Roarable RQD rating, LONA carries an RQD Score of 36 with a letter grade of D-, labeled "Roarable Sell — Vulnerable Balance Sheet & Flow." The five pillars are: Fundamental Cash Engine at 9/20 (ROIC -35%; FCF yield 0%); Whale 13F Flow at 3/20 (institutional accumulation and options positioning); Insider Conviction at 5/20 (SEC Form 4 and Congressional PTR cluster flow); Macro Regime Fit at 9/20 (Beta 1.0; sector sensitivity); and Forensic Balance Sheet at 10/20 (Altman Z 2.5; Piotroski F 2/9; Debt/Equity 0.5). For a prospective investor, the weakest pillars are the cash engine and institutional flow, which indicate that the company is not currently generating returns on invested capital or free cash flow, and that institutional positioning provides little support. The forensic balance sheet score is the strongest of the five, but still sits below the midpoint, and the Piotroski F-Score of 2/9 signals weak fundamental quality. Any upside thesis would need to rest on a change in cash generation or a shift in institutional behavior, neither of which the source data demonstrates.
Business
Per the source profile, LeonaBio Inc. is a NASDAQ-listed issuer in the Health Care sector, operating in the Biotechnology: Biological Products (No Diagnostic Substances) industry. Per the SEC financials, the company reported $0.0M in revenue in each of FY 2023, FY 2024, and FY 2025. Not available in source data for customer base or specific revenue model.
Financial Trend
| Period | Revenue | Operating Income | Net Income | EPS | FCF | Cash | Debt |
|---|---|---|---|---|---|---|---|
| FY 2025 | $0.0M | $-102.3M | $-106.0M | N/A | $-45.7M | $69.3M | N/A |
| FY 2024 | $0.0M | $-100.9M | $-97.0M | N/A | $-97.2M | $48.4M | N/A |
| FY 2023 | $0.0M | $-125.5M | $-117.7M | N/A | $-100.8M | N/A | N/A |
Per the SEC financials, the company reported operating losses across all three periods and no reported revenue. Gross, operating, and net margins are each shown as 0% in the market data, and ROIC is -35%. Per the Roarable RQD rating, the Altman Z-Score is 2.5 and the Piotroski F-Score is 2/9, with a Debt/Equity ratio of 0.5. Per the SEC financials, reported cash was $69.3M at FY 2025 and $48.4M at FY 2024.
Recent Catalysts & News Wire Analysis
- Per the news wire, a director of the company is reported to have acquired shares, with a headline citing a $9.92 billion figure, which appears inconsistent with the $46.3M market capitalization and should be treated as unverified.
- Per the news wire, warrants were exercised at $0.001 per share by Sermonix, and a separate insider filing reports a share purchase and disposal of a warrant exercisable at $0.001.
- Per the news wire, Perceptive Advisors executed 776,648 pre-funded warrants.
- Per the news wire, LONA appeared in a list of quiet movers with no clear catalyst.
- The Perceptive Advisors item is flagged RED under the "RISK WATCH" label; the remaining items are flagged YELLOW under "MARKET WIRE."
- Per the Butterfly Supply-Chain Graph, no supply-chain links or proprietary signals are recorded.
Open Questions
- What is the reported revenue model, and when, if ever, does the company expect to report revenue given $0.0M across the three periods?
- What explains the gap between the $9.92 billion insider-purchase headline and the $46.3M market capitalization?
- What are the warrant and pre-funded warrant terms, and what dilution do they imply relative to the share count?
- What is the company's cash runway given $69.3M in cash against $-45.7M in FY 2025 free cash flow?
- What is the basis for the Roarable RQD sub-scores, and which underlying holder and options data drove the 3/20 whale-flow score?
LONA Live News Feed, Press Releases & Catalyst Wire
Real-time company headlines, analyst actions, and sector developments for LeonaBio Inc. (LONA) • Click "Debate This Headline" to argue it in the Roar Pit below
Investing.com report covering LeonaBio Inc. (LONA) market action, institutional positioning, and fundamental catalysts.
Stock Titan report covering LeonaBio Inc. (LONA) market action, institutional positioning, and fundamental catalysts.
www.marketscreener.com report covering LeonaBio Inc. (LONA) market action, institutional positioning, and fundamental catalysts.
Stock Titan report covering LeonaBio Inc. (LONA) market action, institutional positioning, and fundamental catalysts.
kalkine.ca report covering LeonaBio Inc. (LONA) market action, institutional positioning, and fundamental catalysts.
Kalkine Media report covering LeonaBio Inc. (LONA) market action, institutional positioning, and fundamental catalysts.
Gainers iSpecimen (NASDAQ:ISPC) stock moved upwards by 16.1% to $0.92 during Thursday's after-market session. The company's market cap stands at $2.2 million. CareDx (NASDAQ:CDNA) stock rose 15.0% to $82.25.
Gainers Profusa (NASDAQ:PFSA) shares moved upwards by 35.4% to $1.15 during Thursday's regular session. Karyopharm Therapeutics (NASDAQ:KPTI) shares increased by 29.12% to $0.55. The company's market cap
LONA Bull vs. Bear Conversation Board — What's Your Call at $4.94?
🔥 Official Bull vs. Bear Debate: Is LONA (D- • RQD 36/100) a Buy at $4.91?
Welcome to the LONA (LeonaBio Inc.) Roar Pit. Current RQD Composite is 36/100 (Roarable Sell — Vulnerable Balance Sheet & Flow) in Biotechnology: Biological Products (No Diagnostic Substances). Bulls point to operating leverage and sector positioning, while bears focus on macro rate sensitivity and margin execution. Pick your side (🐂 Bull or 🐻 Bear) and drop your price target below.
Pump the brakes on LONA — check the valuation vs. margin headwinds
Everyone in here is repeating the bull case on LONA, but look at what you are paying: current EV/EBITDA multiples with tightening sector spreads. Unless LeonaBio Inc. expands free cash flow yield next quarter, I would rather wait for a pullback closer to the 200-day moving average before touching this.
LONA cash flow & RQD setup is being underpriced by the Street here
Looking at the 5-pillar RQD breakdown on LONA, the market is fixating on short-term headline noise in Biotechnology: Biological Products (No Diagnostic Substances) and ignoring the balance sheet and cash flow trajectory. At $4.91 (52-wk range $2.21 - $14.21), any beat on forward guidance forces shorts and underweight funds to chase.